Google DeepMind’s watermarked AI proteins still work in the lab

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Google DeepMind has brought its SynthID watermarking technology to synthetic biology. The new tool, SynthID Bio, hides a signature in the amino acid sequence or predicted 3D structure of a protein. The lab announced it on Wednesday in a blog post and a paper in Nature.

Google DeepMind says a test can find the signature in the physical protein as well as in the digital design. In lab tests, it did not change how the proteins worked.

“SynthID Bio is an important piece of the puzzle for tracking the provenance of biological designs,” said Sarah Carter, a biosecurity policy expert at Science Policy Consulting who reviewed the work.

How the mark works

For sequences, SynthID Bio nudges the choice of amino acids. For 3D structures, it adjusts atomic coordinates.

The tool works inside ProteinMPNN, a popular protein design tool from the Baker Lab, John Timmer reported for Ars Technica...

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