Fidji Simo steps down from OpenAI’s number two job

https://media.thenextweb.com/2026/07/Fidji-Simo.avif

Fidji Simo announced her departure from OpenAI’s senior leadership the way many people learn hard news about their own bodies, gradually and then all at once.

In a message on Thursday, she said a three-month medical leave had not gone as hoped, that recovery would be longer and more complicated than expected, and that she would step down as the company’s chief of applications.

Simo joined OpenAI a little over a year ago as CEO of Applications, running product and business and effectively serving as the company’s number two. She had been on leave since April, and the leave has now become an exit. She will remain at the company as a part-time adviser rather than a day-to-day executive.

The reason is medical. Simo said she had experienced a severe exacerbation of postural orthostatic tachycardia syndrome, a chronic neuroimmune condition she was diagnosed with in 2019 that affects heart rate,...

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