Reid Hoffman leaves Microsoft’s board to go ‘founder mode’ with AI drug startup Manus

https://media.thenextweb.com/2026/06/reid-hoffman-leaves-microsoft-board-manus.avif

TL;DR

Reid Hoffman is leaving Microsoft’s board after a decade to focus on Manus, his AI drug discovery startup. The company has raised over $50 million.

Reid Hoffman is stepping down from Microsoft‘s board of directors after nearly a decade. The company disclosed the departure in a regulatory filing on Thursday. Hoffman said he wants to go “founder mode” with Manus, his AI-powered drug discovery startup.

Hoffman joined the board in 2016 after Microsoft bought his company LinkedIn for $26.2 billion. His tenure overlapped with some of the most consequential AI deals in the company’s history. He was a board member when Microsoft invested its first $1 billion into OpenAI in 2019, a bet that reshaped the company’s trajectory.

Hoffman was also one of OpenAI’s original investors and served on that company’s board until 2023. He stepped down citing too many potential conflicts of interest. Those...

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